Is it possible to use Scaler 2 or Scaler 3 with MPE+ hardware like Linnstrument, Expressive E Osmose, Haken Continuum, Roli Seaboard, Embodme Erae Touch?

Is it possible to use Scaler 2 or Scaler 3 with MPE+ hardware like Linnstrument, Expressive E Osmose, Haken Continuum, Roli Seaboard, Embodme Erae Touch, etc ?

And still have the MPE stuff but in a certain scale ?

What do we lose if we use scaler program with MPE+ Hardware for fixed scale ?